Choline Source
CDP-Choline
Also known as: Citicoline
A readily absorbed choline source that supports brain energy and acetylcholine, the brain's memory chemical.
KÖGN Health grades CDP-Choline as A+ (Strong evidence) and rates it 4.4 out of 5.
Last reviewed · June 2026
Primary effects
- Improved memory
- Enhanced focus
- Increased mental energy
How it works
Increases acetylcholine and phospholipid synthesis, enhancing memory and cognitive performance.
Overview
CDP-Choline is one of the most effective choline sources due to its dual role in supporting both neurotransmitter production and brain cell membrane integrity. It contributes to increased mental energy by supporting mitochondrial function in neurons. Compared to other choline sources, it is often preferred for its balanced cognitive effects and strong evidence base.
The evidence
Moderate, growing evidence for attention and focus in healthy adults, with stronger data in older and clinical populations. Among the better-supported choline sources for cognition.
Dose
250–500 mg/day.
Timing
Both — some acute attention effects; benefits also accrue over weeks.
Safety
Well tolerated; occasional mild headache or GI upset. Note: food-supplement permitted levels vary by region — verify the UK/EU limit before formulating.
Works well with
Related ingredients
Graded entries that target the same cognitive goals.
Categories
Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.