Stimulant Alkaloid
Methylliberine
Also known as: Dynamine
A fast-acting stimulant compound similar to caffeine, used to enhance energy and focus.
KÖGN Health grades Methylliberine as B+ (Moderate evidence) and rates it 4.0 out of 5.
Last reviewed · June 2026
Primary effects
- Increased energy
- Improved focus
- Reduced fatigue
How it works
Increases dopaminergic and adenosinergic activity, supporting alertness and mental energy.
Overview
Methylliberine is structurally related to caffeine and theacrine and is often used in energy formulations for its fast onset and relatively smooth stimulation profile. It has a shorter half-life than caffeine, making it useful for acute performance without prolonged stimulation. It is frequently stacked with caffeine to enhance focus while maintaining smoother energy dynamics.
The evidence
Methylliberine (sold as Dynamine) is a purine alkaloid related to theacrine and caffeine, marketed for fast-acting energy and focus, often stacked with the two. Human evidence is very limited — a few short safety and acute-effect studies, frequently in combination products — so any cognitive claim is preliminary.
How to dose it
Acute studies have used roughly 50–200 mg, commonly alongside caffeine and/or theacrine.
When to take it
Acute.
Safety & side effects
Appears well tolerated in the short studies done so far, with a stimulant-like profile; long-term data are lacking.
Who should avoid it
Treat it as a stimulant — caution in pregnancy, anxiety and heart-rhythm conditions — and account for the caffeine it is usually combined with. The evidence base is small and early.
References
Related ingredients
Graded entries that target the same cognitive goals.
Categories
Draft — the dose, safety and evidence notes on this entry were prepared from the published literature and are pending editorial and clinical review.
Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.