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Coenzyme

PQQ

Also known as: Pyrroloquinoline Quinone

A compound that supports mitochondrial function and cellular energy production.

Evidence gradeCross-checked · Moderate-high
B+
WeakModerateStrong
4.0/ 5 rating

KÖGN Health grades PQQ as B+ (Moderate evidence) and rates it 4.0 out of 5.

Last reviewed · June 2026

CategoryNatural · Coenzyme
AvailabilityOTC

Primary effects

  • Increased energy
  • Neuroprotection
  • Mitochondrial support

How it works

Promotes mitochondrial biogenesis and supports cellular energy metabolism.

Overview

PQQ is a redox cofactor that has been studied for its role in stimulating mitochondrial biogenesis, potentially improving cellular energy efficiency. It is often paired with CoQ10 for synergistic effects on energy metabolism. While human research is still emerging, it shows promise for long-term brain health and cognitive resilience rather than immediate performance enhancement.

Related ingredients

Graded entries that target the same cognitive goals.

Categories

Natural NootropicsBrain Energy & MetabolismNeuroprotection & LongevityCellular SupportLong-Term Cognitive SupportOver-the-Counter (OTC)Moderate-High Evidence

Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.