Vitamin B6 Derivative
Pyritinol
A semi-synthetic compound derived from vitamin B6 used to support cognition and cerebral metabolism.
KÖGN Health grades Pyritinol as B (Moderate evidence) and rates it 3.8 out of 5.
Last reviewed · June 2026
Primary effects
- Improved memory
- Increased mental energy
- Cognitive support
How it works
Improves glucose utilisation in the brain and may support cognitive efficiency under stress.
Overview
Pyritinol has been studied for its potential effects on cognitive performance, particularly in ageing populations and conditions involving reduced cerebral metabolism. While some studies suggest modest benefits, the evidence is mixed and not as strong as more established nootropics. It is generally considered a mild cognitive enhancer rather than a core foundational compound.
The evidence
Pyritinol is a synthetic molecule made of two vitamin-B6 units, studied decades ago for dementia and 'organic brain syndrome' with some older positive trials. The evidence is dated and of limited quality, and it is rarely used today, partly because of safety concerns.
How to dose it
Older clinical studies used around 600 mg/day; it is uncommon now and quality control varies.
When to take it
Chronic.
Safety & side effects
The notable concern is rare but serious: cases of cholestatic liver injury and pancreatitis have been reported, which is why it fell out of favour.
Who should avoid it
Avoid with liver or pancreatic disease, and stop and seek care for abdominal pain, nausea or jaundice. Given the dated evidence and safety signals, better-supported choline or B-vitamin options are usually preferable — discuss with a clinician.
References
Related ingredients
Graded entries that target the same cognitive goals.
Categories
Draft — the dose, safety and evidence notes on this entry were prepared from the published literature and are pending editorial and clinical review.
Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.