Cerebral Vasodilator
Vinpocetine
A compound derived from vincamine used to support cerebral blood flow and cognitive function.
KÖGN Health grades Vinpocetine as B+ (Moderate evidence) and rates it 4.0 out of 5.
Last reviewed · June 2026
Primary effects
- Improved memory
- Increased focus
- Cognitive support
How it works
Improves blood flow and oxygen utilisation in the brain.
Overview
Vinpocetine is used to enhance cerebral circulation and support cognitive performance, particularly in ageing populations. It may improve oxygen and glucose utilisation in the brain, contributing to mental clarity. However, regulatory status varies by region, and long-term safety data is still being evaluated.
The evidence
Vinpocetine, derived from the periwinkle alkaloid vincamine, is used in several countries for cerebrovascular disorders. A Cochrane review concluded there is insufficient evidence to support its use for cognitive impairment or dementia, and it failed to help in Alzheimer's trials. The cognitive case in healthy people is weak; its safety record, however, is good.
How to dose it
Studied at roughly 15–30 mg/day, usually split and taken with food.
When to take it
Both — some acute cerebral-blood-flow effects, studied over weeks.
Safety & side effects
Generally well tolerated; occasional GI upset, flushing or sleep disturbance.
Who should avoid it
Regulators have flagged that vinpocetine is not a lawful dietary-supplement ingredient in some regions (including the US), and that it may cause harm in pregnancy (reduced fetal growth) — it should be avoided by anyone pregnant or who may become pregnant. It can also have mild blood-thinning effects; discuss with a clinician if you take anticoagulants.
References
Related ingredients
Graded entries that target the same cognitive goals.
Categories
Draft — the dose, safety and evidence notes on this entry were prepared from the published literature and are pending editorial and clinical review.
Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.