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Vitamin

Vitamin B6

Also known as: Pyridoxine, P5P

An essential vitamin involved in neurotransmitter synthesis and brain metabolism.

Evidence gradeCross-checked · High
A
WeakModerateStrong
4.3/ 5 rating

KÖGN Health grades Vitamin B6 as A (Strong evidence) and rates it 4.3 out of 5.

Last reviewed · June 2026

CategoryNutritional · Vitamin
AvailabilityOTC

Primary effects

  • Improved mood
  • Cognitive support
  • Neurotransmitter balance

How it works

Supports synthesis of serotonin, dopamine, and GABA, influencing mood and cognition.

Overview

Vitamin B6 (especially in its active form P5P) plays a key role in amino acid metabolism and neurotransmitter production. Adequate levels are essential for healthy brain function, and deficiency can significantly impact mood and cognitive performance. Supplementation is most beneficial when dietary intake is insufficient or metabolic demand is high.

Related ingredients

Graded entries that target the same cognitive goals.

Vitamin B Complex · A+ →Vitamin B9 · A+ →Omega-3 · A →

Categories

Nutritional NootropicsMood & Emotional RegulationBrain Energy & MetabolismSerotonergics (Serotonin Support)Dopaminergics (Dopamine Support)Daily Foundational NootropicsOver-the-Counter (OTC)High Evidence

Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.