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Serotonin Precursor

5-HTP

Also known as: 5-Hydroxytryptophan

A compound that supports serotonin production, influencing mood, sleep, and emotional balance.

Evidence gradeCross-checked · Moderate-high
B+
WeakModerateStrong
4.0/ 5 rating

KÖGN Health grades 5-HTP as B+ (Moderate evidence) and rates it 4.0 out of 5.

Last reviewed · June 2026

CategoryNatural · Serotonin Precursor
AvailabilityOTC

Primary effects

  • Improved mood
  • Better sleep
  • Stress reduction

How it works

Increases serotonin levels, supporting mood regulation and sleep quality.

Overview

5-HTP is a direct precursor to serotonin and is commonly used to support mood and sleep regulation. It can be effective for short-term mood support, but should be used cautiously due to its strong influence on serotonin pathways. It is often paired carefully with other compounds to avoid overstimulation of serotonin systems.

Related ingredients

Graded entries that target the same cognitive goals.

Categories

Natural NootropicsMood & Emotional RegulationSleep & RecoverySerotonergics (Serotonin Support)Acute Performance NootropicsOver-the-Counter (OTC)Moderate-High Evidence

Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.