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GABA Analog

Phenibut

A GABA-derivative compound used to reduce anxiety and promote relaxation.

Evidence gradeCross-checked · Moderate-high
B+
WeakModerateStrong
4.0/ 5 rating

KÖGN Health grades Phenibut as B+ (Moderate evidence) and rates it 4.0 out of 5.

Last reviewed · June 2026

CategorySynthetic · GABA Analog
AvailabilityResearch

Primary effects

  • Reduced anxiety
  • Improved mood
  • Relaxation

How it works

Activates GABA-B receptors, producing calming and anxiolytic effects.

Overview

Phenibut is known for its strong anxiolytic effects, making it effective for reducing social anxiety and stress. However, it carries a significant risk of tolerance, dependence, and withdrawal with frequent use. Because of this, it is best used sparingly and not as a daily supplement. It is more aligned with situational or occasional use rather than foundational cognitive enhancement.

Related ingredients

Graded entries that target the same cognitive goals.

Ashwagandha · A →Withania Somnifera · A →Kava · B+ →

Categories

Synthetic NootropicsStress & Anxiety ReductionMood & Emotional RegulationGABAergics (Calming / Inhibitory Support)Acute Performance NootropicsExperimental / Research CompoundsModerate-High Evidence

Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.