Atypical Antidepressant
Tianeptine
A compound that acts on the brain's glutamate signalling to influence mood and thinking.
KÖGN Health grades Tianeptine as B+ (Moderate evidence) and rates it 4.0 out of 5.
Last reviewed · June 2026
Primary effects
- Mood improvement
- Stress reduction
- Cognitive support
How it works
Regulates glutamate signalling and supports mood and stress response systems.
Overview
Tianeptine is an atypical compound with antidepressant properties that also influences glutamatergic activity in the brain. It has been studied for its effects on mood, anxiety, and cognitive function. However, it carries a significant risk of dependence and misuse potential, which limits its suitability as a general nootropic. Its use should be approached with caution.
Related ingredients
Graded entries that target the same cognitive goals.
Categories
Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.