Vitamin
Vitamin K2
A fat-soluble vitamin that supports cardiovascular and brain health through calcium regulation.
KÖGN Health grades Vitamin K2 as B (Moderate evidence) and rates it 3.9 out of 5.
Last reviewed · June 2026
Primary effects
- Neuroprotection
- Vascular support
- Cognitive health
How it works
Supports vascular health and calcium regulation, indirectly benefiting brain function.
Overview
Vitamin K2 is primarily known for its role in directing calcium to bones and away from soft tissues, supporting cardiovascular health. Indirectly, this may benefit brain function by maintaining healthy blood vessels and circulation. While not a direct nootropic, it contributes to long-term neurological health as part of a broader nutritional profile.
The evidence
Vitamin K2's established roles are in blood clotting, bone and cardiovascular health; the brain angle is newer. It contributes to the synthesis of sphingolipids (important brain-membrane fats), and observational data link better vitamin K status to sharper cognition in older adults — but there are no good randomised trials of K2 supplementation for cognition. The brain case is largely indirect, via vascular and metabolic health.
How to dose it
Supplements commonly provide 90–180 µg/day of K2 (often as MK-7), taken with a fat-containing meal.
When to take it
Chronic.
Safety & side effects
Very well tolerated, with no established toxicity at normal supplement doses.
Who should avoid it
The important interaction is with warfarin and similar anticoagulants: vitamin K opposes their effect, so do not start, stop or change a K2 supplement without telling the clinician who manages your anticoagulation. Otherwise low-risk.
References
Related ingredients
Graded entries that target the same cognitive goals.
Categories
Draft — the dose, safety and evidence notes on this entry were prepared from the published literature and are pending editorial and clinical review.
Educational information, not medical advice. The evidence grade is KÖGN’s editorial assessment of published research, not a health claim. Speak to a qualified clinician before changing what you take.